BDBM50044080 2-Amino-5-[1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-meth-(Z)-ylidene]-thiazol-4-one; compound with methanesulfonic acid::CHEMBL109745::CHEMBL196996::CHEMBL275835::Darbufelone mesylate
SMILES CC(C)(C)c1cc(C=C2SC(N)=NC2=O)cc(c1O)C(C)(C)C
InChI Key InChIKey=AKTXOQVMWSFEBQ-UHFFFAOYSA-N
Data 7 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50044080
Affinity DataIC50: 770nMAssay Description:Inhibition of 5-lipoxygenase in intact rat basophilic leukemia cells stimulated with the calciumionophore A-23,187More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:IC50 against Prostaglandin G/H synthase 1 from human platelet rich plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:IC50 value was determined against Prostaglandin G/H synthase 2 of J7744A.1 cell lines.More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories
Curated by ChEMBL
Organon Laboratories
Curated by ChEMBL
Affinity DataIC50: 770nMAssay Description:Inhibitory concentration against arachidonate 5-lipoxygenaseMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Oryctolagus cuniculus)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.76E+4nMAssay Description:Inhibition of COX-1 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs by HPLC in presence of c...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Oryctolagus cuniculus)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...More data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibitory concentration against prostaglandin G/H synthaseMore data for this Ligand-Target Pair