BDBM50045367 (20RS)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::(20S)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::9-Aminocamptothecin::CHEMBL315269

SMILES CCC1(O)C(=O)OCc2c1cc1-c3nc4cccc(N)c4cc3Cn1c2=O

InChI Key InChIKey=FUXVKZWTXQUGMW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50045367   

TargetDNA topoisomerase 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045367((20RS)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-...)
Affinity DataIC50:  840nMAssay Description:Inhibition of Topoisomerase I by cleavage complex formation in intact human HL-60 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045367((20RS)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-...)
Affinity DataIC50:  440nMAssay Description:Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed