BDBM50045654 CHEMBL96253::N-{4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-3-thia-1-aza-acenaphthylen-2-yl]-3,3-dimethyl-butyryl}-methanesulfonamide

SMILES CC1Cc2c(OCc3ccc(cn3)-c3ccccc3)ccc3n(Cc4ccc(Cl)cc4)c(CC(C)(C)CC(=O)NS(C)(=O)=O)c(S1)c23

InChI Key InChIKey=PMCLXOFWBAQLHI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50045654   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50045654(CHEMBL96253 | N-{4-[1-(4-Chloro-benzyl)-4-methyl-6...)
Affinity DataIC50:  36nMAssay Description:In vitro test for inhibition of 5-lipoxygenase in cell-free preparations from rat PMN leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50045654(CHEMBL96253 | N-{4-[1-(4-Chloro-benzyl)-4-methyl-6...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition of LTB4 biosynthesis in [Ca2+]-ionophore-activated human polymorphonuclear leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed