BDBM50046910 4-(5-Amino-[1,3,4]thiadiazol-2-yl)-2,6-di-tert-butyl-phenol::CHEMBL417073

SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)-c1nnc(N)s1

InChI Key InChIKey=ZCHIJNKLPIPVGQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50046910   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50046910(4-(5-Amino-[1,3,4]thiadiazol-2-yl)-2,6-di-tert-but...)
Affinity DataIC50:  530nMAssay Description:IC50 value against Prostaglandin G/H synthase 1 of human platelet rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50046910(4-(5-Amino-[1,3,4]thiadiazol-2-yl)-2,6-di-tert-but...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of 5-lipoxygenase measured by the reduction of leukotriene B4 (LTB4) in intact basophilic rat leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50046910(4-(5-Amino-[1,3,4]thiadiazol-2-yl)-2,6-di-tert-but...)
Affinity DataIC50:  110nMAssay Description:IC50 value against Prostaglandin G/H synthase 2 of murine J774A.1 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50046910(4-(5-Amino-[1,3,4]thiadiazol-2-yl)-2,6-di-tert-but...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of recombinant human prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed