BDBM50048172 CHEMBL3310485

SMILES Fc1cccc(OC(CC2CNC2)c2ccc(Cl)c(F)c2)c1

InChI Key InChIKey=JAJZURBQJLCEQE-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50048172   

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50048172(CHEMBL3310485)
Affinity DataIC50:  37nMAssay Description:Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50048172(CHEMBL3310485)
Affinity DataIC50:  15nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50048172(CHEMBL3310485)
Affinity DataIC50:  36nMAssay Description:Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50048172(CHEMBL3310485)
Affinity DataIC50:  1.46E+3nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50048172(CHEMBL3310485)
Affinity DataIC50:  210nMAssay Description:Inhibition of recombinant human CYP2C19 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50048172(CHEMBL3310485)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of recombinant human CYP2D6 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50048172(CHEMBL3310485)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of recombinant human CYP2C9 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50048172(CHEMBL3310485)
Affinity DataIC50:  510nMAssay Description:Inhibition of recombinant human CYP3A4 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50048172(CHEMBL3310485)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of recombinant human CYP1A2 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed