BDBM50048954 (R)-2-Amino-3-(biphenyl-4-ylamino)-propane-1-thiol::2-Amino-3-(biphenyl-4-ylamino)-propane-1-thiol 7(FTI-268)::CHEMBL55527

SMILES N[C@@H](CS)CNc1ccc(cc1)-c1ccccc1

InChI Key InChIKey=LTTNTQLMUPSHOL-CQSZACIVSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50048954   

LigandPNGBDBM50048954((R)-2-Amino-3-(biphenyl-4-ylamino)-propane-1-thiol...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048954((R)-2-Amino-3-(biphenyl-4-ylamino)-propane-1-thiol...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50048954((R)-2-Amino-3-(biphenyl-4-ylamino)-propane-1-thiol...)
Affinity DataIC50:  1.07E+3nMAssay Description:In vitro inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50048954((R)-2-Amino-3-(biphenyl-4-ylamino)-propane-1-thiol...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed