BDBM50048960 4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3-carboxylic acid methyl ester::4'-(2-Amino-3-mercapto-propylamino)-biphenyl-3-carboxylic acid methyl ester 5(FTI-259)::CHEMBL53732

SMILES COC(=O)c1cccc(c1)-c1ccc(NC[C@@H](N)CS)cc1

InChI Key InChIKey=XJBBINSSZZHBDZ-OAHLLOKOSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50048960   

TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50048960(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)
Affinity DataIC50:  930nMAssay Description:Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048960(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50048960(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)
Affinity DataIC50:  917nMAssay Description:In vitro inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048960(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed