BDBM50054258 CHEMBL3319377::US9522881, 11a-22 L97L07::US9844535, ID 11a-22 L97L07

SMILES Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)Nc2ccc(cc2)-c2cccc(c2)C#N)c1

InChI Key InChIKey=XDVMDMDHVZOAMP-UHFFFAOYSA-N

Data  3 IC50

PDB links: 38 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50054258   

TargetPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(Homo sapiens (Human))
Indiana University Research and Technology

US Patent
LigandPNGBDBM50054258(CHEMBL3319377 | US9522881, 11a-22 L97L07 | US98445...)
Affinity DataIC50:  310nMpH: 7.0Assay Description:The inhibition assays were performed at 25° C. in 50 mM 3,3-dimethylglutarate buffer, pH 7.0, containing 1 mM EDTA with an ionic strength of 0.15M ad...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(Homo sapiens (Human))
Indiana University Research and Technology

US Patent
LigandPNGBDBM50054258(CHEMBL3319377 | US9522881, 11a-22 L97L07 | US98445...)
Affinity DataIC50:  310nMAssay Description:PTP assays were conducted as previously described in Kontaridis et al., J Biol Chem. 2006; 281:6785-6792, using para-nitrophenyl phosphate (pNPP, obt...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50054258(CHEMBL3319377 | US9522881, 11a-22 L97L07 | US98445...)
Affinity DataIC50:  310nMAssay Description:Inhibition of SHP2 (unknown origin) using p-nitrophenyl phosphate substrate by microplate spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed