BDBM50055371 (3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-indol-4-yloxy)-acetic acid::CHEMBL357979

SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1-c1ccccc1

InChI Key InChIKey=KFJOAXDOAYZVOY-UHFFFAOYSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50055371   

TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  364nMAssay Description:Compound was tested for inhibition of human secretory pancreatic Phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, major isoenzyme(Sus scrofa (pig))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  97nMAssay Description:Compound was tested for inhibition of porcine secretory pancreatic Phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human nonpancreatic secretory Phospholipase A2 through DOC/PC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human group IB PLA2 in [3H]oleate-labeled Escherichia coli membrane by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, major isoenzyme(Sus scrofa (pig))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  97nMAssay Description:Inhibition of pig group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGroup 10 secretory phospholipase A2(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  4.57E+3nMAssay Description:Inhibition of human group X PLA2 in [3H]oleate-labeled Escherichia coli membrane by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2 group V(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  270nMAssay Description:Inhibition of human group V PLA2 in [3H]oleate-labeled Escherichia coli membrane by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhospholipase A2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  364nMAssay Description:Inhibition of human group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human group IIA PLA2 in [3H]oleate-labeled Escherichia coli membrane by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed