BDBM50056163 (S)-2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylamino)butan-1-ol::(S)-2-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-butan-1-ol::CHEMBL133342

SMILES CC[C@@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1

InChI Key InChIKey=BTIHMVBBUGXLCJ-HNNXBMFYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50056163   

TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Charles University

Curated by ChEMBL
LigandPNGBDBM50056163((S)-2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylam...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50056163((S)-2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylam...)
Affinity DataEC50:  5.70E+5nMAssay Description:Agonist activity at N-type Cav2.2 channel expressed in tsA201 cell assessed as calcium current by whole-cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50056163((S)-2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylam...)
Affinity DataIC50:  200nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))TBA
LigandPNGBDBM50056163((S)-2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylam...)
Affinity DataIC50:  500nMAssay Description:Binding affinity towards human beta-3 adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Charles University

Curated by ChEMBL
LigandPNGBDBM50056163((S)-2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylam...)
Affinity DataIC50:  650nMAssay Description:Inhibition of CDC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50056163((S)-2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylam...)
Affinity DataIC50:  230nMAssay Description:Inhibition of 125I-[Phe13,Tyr19]-MCH binding to MCH-R1 expressing cell membranes at 1uMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50056163((S)-2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylam...)
Affinity DataIC50:  100nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as concentration required to incapacitate 50% of the population exposed to t...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50056163((S)-2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylam...)
Affinity DataIC50:  700nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed