BDBM50057402 CHEMBL3322777

SMILES COc1ccc-2c(NC3(CCN(CC3)C(=O)c3ccc(OC)c(c3)N(C)C)c3cccn-23)c1

InChI Key InChIKey=CSGMIVCOTWOCPC-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50057402   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50057402(CHEMBL3322777)
Affinity DataIC50:  9nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells assessed as membrane potential after 60 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50057402(CHEMBL3322777)
Affinity DataIC50:  351nMAssay Description:Inhibition of human Nav1.5 channel expressed in HEK293 cells assessed as membrane potential after 60 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50057402(CHEMBL3322777)
Affinity DataIC50:  331nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50057402(CHEMBL3322777)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by voltage clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50057402(CHEMBL3322777)
Affinity DataIC50:  9nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 60 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50057402(CHEMBL3322777)
Affinity DataIC50:  572nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells after 60 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50057402(CHEMBL3322777)
Affinity DataIC50:  331nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by voltage clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50057402(CHEMBL3322777)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of human Nav1.5 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed