BDBM50058453 2-Ethyl-1-(4-trifluoromethoxy-phenyl)-isothiourea; hydrochloride::CHEMBL500922::CHEMBL554651

SMILES CCSC(N)=Nc1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=LDRUFSWQOURAKN-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50058453   

TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50058453(2-Ethyl-1-(4-trifluoromethoxy-phenyl)-isothiourea;...)
Affinity DataKi:  700nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50058453(2-Ethyl-1-(4-trifluoromethoxy-phenyl)-isothiourea;...)
Affinity DataKi:  700nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase in brain (nNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50058453(2-Ethyl-1-(4-trifluoromethoxy-phenyl)-isothiourea;...)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibitory activity against human vascular endothelial nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50058453(2-Ethyl-1-(4-trifluoromethoxy-phenyl)-isothiourea;...)
Affinity DataKi:  5.50E+4nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed