BDBM50058715 CHEMBL64360::EMD-96785::ENIPORIDE::N-(5-Methanesulfonyl-2-methyl-4-pyrrol-1-yl-benzoyl)-guanidine::N-(5-Methanesulfonyl-2-methyl-4-pyrrol-1-yl-benzoyl)-guanidine (Eniporide, EMD-96-875)::N-(diaminomethylene)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide
SMILES Cc1cc(c(cc1C(=O)NC(N)=N)S(C)(=O)=O)-n1cccc1
InChI Key InChIKey=UADMBZFZZOBWBB-UHFFFAOYSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50058715
Affinity DataIC50: 9.20E+3nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:In vitro concentration required to inhibit NHE-1 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Compound is screened in AP1 cells expressing human NHE-3 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 5(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Compound is screened in AP1 cells expressing human NHE-5 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of 5-N-(ethyl isopropyl)-amiloride[EIPA]-sensitive Na+ uptake into acidified rabbit erythrocytes.More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:Compound is screened in AP1 cells expressing human NHE-2 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human NHE2 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of human NHE1 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Sodium/hydrogen exchanger antiport activity was measured using [22]Na+ uptake inhibition assay in acidified rabbit erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair