BDBM50059309 CHEMBL3393446

SMILES N#CCC1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

InChI Key InChIKey=OVLGSAZYDZSQMN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50059309   

TargetSerine/threonine-protein kinase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50059309(CHEMBL3393446)
Affinity DataIC50:  196nMAssay Description:Inhibition of human recombinant MST2 using Ser/Thr peptide 7 substrate after 45 mins by Z-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50059309(CHEMBL3393446)
Affinity DataIC50:  5nMAssay Description:Inhibition of GST-tagged truncated human recombinant LRRK2 using fluorescein-labeled LRRKtide peptide substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50059309(CHEMBL3393446)
Affinity DataIC50:  117nMAssay Description:Inhibition of full length LRRK2 (unknown origin) expressed in HEK293 cells assessed as reduction in S935 phosphorylation incubated for 90 mins by ELI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed