BDBM50063129 (R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophene-2-sulfonylamino)-propionic acid::CHEMBL297792

SMILES Cc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O

InChI Key InChIKey=YWCLDDLVLSQGSZ-JOCHJYFZSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50063129   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50:  9.60nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloproteinase-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against endothelin converting enzyme (ECE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed