BDBM50063990 5-((biphenyl-2-ylamino)methyl)furo[2,3-d]pyrimidine-2,4-diamine::5-(Biphenyl-2-ylaminomethyl)-furo[2,3-d]pyrimidine-2,4-diamine::CHEMBL23960

SMILES Nc1nc(N)c2c(CNc3ccccc3-c3ccccc3)coc2n1

InChI Key InChIKey=PAKCUGXRBKIEAD-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50063990   

TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063990(5-((biphenyl-2-ylamino)methyl)furo[2,3-d]pyrimidin...)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase from pneumocystis carniiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063990(5-((biphenyl-2-ylamino)methyl)furo[2,3-d]pyrimidin...)
Affinity DataIC50:  4.54E+4nMAssay Description:Inhibitory activity against dihydrofolate reductase from Toxoplasma gondiiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063990(5-((biphenyl-2-ylamino)methyl)furo[2,3-d]pyrimidin...)
Affinity DataIC50:  1.37E+5nMAssay Description:Inhibitory activity against dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50063990(5-((biphenyl-2-ylamino)methyl)furo[2,3-d]pyrimidin...)
Affinity DataIC50:  7.70E+3nMAssay Description:In vitro inhibition of Pneumocystis carinii (Pc) dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063990(5-((biphenyl-2-ylamino)methyl)furo[2,3-d]pyrimidin...)
Affinity DataIC50:  1.37E+5nMAssay Description:Inhibition of rat liver DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063990(5-((biphenyl-2-ylamino)methyl)furo[2,3-d]pyrimidin...)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063990(5-((biphenyl-2-ylamino)methyl)furo[2,3-d]pyrimidin...)
Affinity DataIC50:  4.54E+4nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063990(5-((biphenyl-2-ylamino)methyl)furo[2,3-d]pyrimidin...)
Affinity DataIC50:  4.54E+4nMAssay Description:Inhibition of Toxoplasma gondii DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063990(5-((biphenyl-2-ylamino)methyl)furo[2,3-d]pyrimidin...)
Affinity DataIC50:  1.37E+5nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed