BDBM50065454 CHEBI:63453::CHEMBL3348846

SMILES COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1

InChI Key InChIKey=VRQMAABPASPXMW-HDICACEKSA-N

Data  79 IC50  3 Kd  2 Kon

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50065454   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of recombinant FGFR3 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  46nMAssay Description:Inhibition of recombinant FGFR4 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  33nMAssay Description:Inhibition of FGFR1 in human H1581 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50: <0.200nMAssay Description:Inhibition of FGFR1 in human KG1 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  20nMAssay Description:Inhibition of FGFR2 in human KATO III cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of FGFR3 in human RT112 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of recombinant FGFR2 in human SNU16 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of recombinant FGFR2 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed