BDBM50065640 CHEMBL3401455
SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-n2cncn2)c1
InChI Key InChIKey=GAVZCGTYRWKKDV-UHFFFAOYSA-N
Data 12 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50065640
Affinity DataIC50: 209nMAssay Description:Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 224nMAssay Description:Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 30 mins by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 257nMAssay Description:Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 60 mins by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 309nMAssay Description:Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 90 mins by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid by HPLC analysisMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
University Of Eastern Finland
Curated by ChEMBL
University Of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 7.24E+3nMAssay Description:Inhibition of human FAAH expressed in COS7 cell membranes pre-incubated for 10 mins before [3H]-AEA substrate addition by liquid scintillation counti...More data for this Ligand-Target Pair
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
University Of Eastern Finland
Curated by ChEMBL
University Of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of human ABHD6 containing pCMV6-AC-hABHD6 transfected into HEK293 cellsMore data for this Ligand-Target Pair
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
University Of Eastern Finland
Curated by ChEMBL
University Of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of human ABHD6 expressed in HEK293 cells assessed as reduction in glycerol production from 1-AG hydrolysis pre-incubated for 30 mins befor...More data for this Ligand-Target Pair
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
University Of Eastern Finland
Curated by ChEMBL
University Of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of human ABHD6 expressed in HEK293 cells assessed as reduction in glycerol production from 1-AG hydrolysis pre-incubated for 30 mins befor...More data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of human MAGL expressed in HEK293 cells pre-incubated for 10 mins before 2-AG substrate addition by HPLC methodMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
University Of Eastern Finland
Curated by ChEMBL
University Of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 7.24E+3nMAssay Description:Inhibition of human FAAH expressed in COS7 cell membranes pre-incubated for 10 mins before [3H]-AEA substrate addition by liquid scintillation counti...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
University Of Eastern Finland
Curated by ChEMBL
University Of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 7.24E+3nMAssay Description:Inhibition of human FAAH using [ethanolamine 1-3H] substrate assessed as radioactivity by liquid scintillation counting analysisMore data for this Ligand-Target Pair