BDBM50066430 2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phenyl)-pyrimidin-4-ylamine::2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phenyl)-pyrimidin-4-ylamine(BW619C89)::CHEMBL28854::SIPATRIGINE
SMILES CN1CCN(CC1)c1ncc(c(N)n1)-c1cc(Cl)cc(Cl)c1Cl
InChI Key InChIKey=PDOCBJADCWMDGL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50066430
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Boehringer Ingelheim Pharma
Curated by ChEMBL
Boehringer Ingelheim Pharma
Curated by ChEMBL
Affinity DataKi: 4.00E+3nMAssay Description:Displacement of [3H]BTX from sodium channel of rat cerebral cortex synaptosomesMore data for this Ligand-Target Pair
Affinity DataIC50: 2.55E+3nMAssay Description:Blockade of synaptosomal sodium channels, inhibition of [14C]-guanidinium ion flux into CHO cells expressing Type II sodium channelMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Cambridge Neuroscience
Curated by ChEMBL
Cambridge Neuroscience
Curated by ChEMBL
Affinity DataIC50: 2.55E+3nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Boehringer Ingelheim Pharma
Curated by ChEMBL
Boehringer Ingelheim Pharma
Curated by ChEMBL
Affinity DataIC50: 1.79E+4nMAssay Description:Inhibitory effect against veratridine-induced glutamate release from rat brain slicesMore data for this Ligand-Target Pair
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Korea Institute of Science and Technology
Korea Institute of Science and Technology
Affinity DataEC50: 4.00E+3nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Korea Institute of Science and Technology
Korea Institute of Science and Technology
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of of human TREK1 expressed in HEK293 cells assessed as reversible current depressionMore data for this Ligand-Target Pair