BDBM50066430 2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phenyl)-pyrimidin-4-ylamine::2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phenyl)-pyrimidin-4-ylamine(BW619C89)::CHEMBL28854::SIPATRIGINE

SMILES CN1CCN(CC1)c1ncc(c(N)n1)-c1cc(Cl)cc(Cl)c1Cl

InChI Key InChIKey=PDOCBJADCWMDGL-UHFFFAOYSA-N

Data  1 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50066430   

TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50066430(2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phe...)
Affinity DataKi:  4.00E+3nMAssay Description:Displacement of [3H]BTX from sodium channel of rat cerebral cortex synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50066430(2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phe...)
Affinity DataIC50:  2.55E+3nMAssay Description:Blockade of synaptosomal sodium channels, inhibition of [14C]-guanidinium ion flux into CHO cells expressing Type II sodium channelMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Cambridge Neuroscience

Curated by ChEMBL
LigandPNGBDBM50066430(2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phe...)
Affinity DataIC50:  2.55E+3nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50066430(2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phe...)
Affinity DataIC50:  1.79E+4nMAssay Description:Inhibitory effect against veratridine-induced glutamate release from rat brain slicesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Korea Institute of Science and Technology

LigandPNGBDBM50066430(2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phe...)
Affinity DataEC50:  4.00E+3nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Korea Institute of Science and Technology

LigandPNGBDBM50066430(2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phe...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of of human TREK1 expressed in HEK293 cells assessed as reversible current depressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed