BDBM50069065 (2R,3R)-2,3-Dimethyl-5-trifluoromethyl-1,2,3,8-tetrahydro-pyrrolo[3,2-g]quinolin-7-one::CHEMBL162569

SMILES C[C@H]1Nc2cc3[nH]c(=O)cc(c3cc2[C@H]1C)C(F)(F)F

InChI Key InChIKey=JEKLOWJNFQMNLW-NKWVEPMBSA-N

Data  1 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50069065   

TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069065((2R,3R)-2,3-Dimethyl-5-trifluoromethyl-1,2,3,8-tet...)
Affinity DataKi:  6nMAssay Description:Binding affinity against Androgen receptor transfected into COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069065((2R,3R)-2,3-Dimethyl-5-trifluoromethyl-1,2,3,8-tet...)
Affinity DataEC50:  5nMAssay Description:Agonistic activity (EC50) against human androgen receptor (hAR) in cotransfected CV-1 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069065((2R,3R)-2,3-Dimethyl-5-trifluoromethyl-1,2,3,8-tet...)
Affinity DataIC50:  2.00E+3nMAssay Description:Antagonistic activity against hMR in cotransfected CV-1 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069065((2R,3R)-2,3-Dimethyl-5-trifluoromethyl-1,2,3,8-tet...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against hAR androgen receptor expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069065((2R,3R)-2,3-Dimethyl-5-trifluoromethyl-1,2,3,8-tet...)
Affinity DataIC50:  1.90E+3nMAssay Description:Antagonistic activity against hPR in cotransfected CV-1 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069065((2R,3R)-2,3-Dimethyl-5-trifluoromethyl-1,2,3,8-tet...)
Affinity DataIC50:  2.50E+3nMAssay Description:Antagonistic activity against Glucocorticoid receptor in cotransfected CV-1 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed