BDBM50069344 CHEMBL3403537::US9688661, 4-(5-Chloro-2-methylphenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrrole-3-carboxamide (compd 270)

SMILES Cc1ccc(Cl)cc1-c1cn(cc1C(N)=O)-c1ncnc2[nH]ccc12

InChI Key InChIKey=RKUFUTNRBJSUDP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50069344   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50069344(CHEMBL3403537 | US9688661, 4-(5-Chloro-2-methylphe...)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50069344(CHEMBL3403537 | US9688661, 4-(5-Chloro-2-methylphe...)
Affinity DataIC50:  43nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50069344(CHEMBL3403537 | US9688661, 4-(5-Chloro-2-methylphe...)
Affinity DataIC50:  17nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [861-1152](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50069344(CHEMBL3403537 | US9688661, 4-(5-Chloro-2-methylphe...)
Affinity DataIC50:  85nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In DepthDetails US Patent