BDBM50069511 (2-Ethyl-quinazolin-4-yl)-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amine::(2-Ethyl-quinazolin-4-yl)-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amine::CHEMBL48270

SMILES CCc1nc(NCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ccccc2n1

InChI Key InChIKey=YXOFHDKVTPPXQP-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50069511   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50069511((2-Ethyl-quinazolin-4-yl)-[2'-(1H-tetrazol-5-yl)-b...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibitory effect in cGMP-inhibited Phosphodiesterase 3 (PDE 3) isolated from guinea pig ventricular tissue.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
TBA

Curated by ChEMBL
LigandPNGBDBM50069511((2-Ethyl-quinazolin-4-yl)-[2'-(1H-tetrazol-5-yl)-b...)
Affinity DataKd:  2.95nMAssay Description:pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50069511((2-Ethyl-quinazolin-4-yl)-[2'-(1H-tetrazol-5-yl)-b...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibitory effect in cAMP-specific Phosphodiesterase 4 (PDE 4) isolated from guinea pig ventricular tissue.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed