BDBM50069900 2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)acetylsulfamate::AVASIMIBE::CHEMBL101309::CI-1011::[2-(2,4,6-Triisopropyl-phenyl)-acetyl]-sulfamic acid 2,6-diisopropyl-phenyl ester

SMILES CC(C)c1cc(C(C)C)c(CC(=O)NS(=O)(=O)Oc2c(cccc2C(C)C)C(C)C)c(c1)C(C)C

InChI Key InChIKey=PTQXTEKSNBVPQJ-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50069900   

TargetSterol O-acyltransferase 1(Mus musculus)
Kowa

Curated by ChEMBL
LigandPNGBDBM50069900(2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)...)
Affinity DataIC50:  760nMAssay Description:Inhibition of ACAT1 in mouse IC21 cells in presence of BSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kowa

Curated by ChEMBL
LigandPNGBDBM50069900(2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of ACAT1 in human monocytes-derived macrophages reduction in cholesteryl oleate formation preincubated for 2 hrs followed by [14C]-oleic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Kowa

Curated by ChEMBL
LigandPNGBDBM50069900(2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)...)
Affinity DataIC50:  700nMAssay Description:Inhibition of ACAT1 in 0.2 mg/ml rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kowa

Curated by ChEMBL
LigandPNGBDBM50069900(2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)...)
Affinity DataIC50:  25nMAssay Description:Inhibition of ACAT1 in human monocytes-derived macrophages reduction in cholesteryl oleate formation preincubated for 2 hrs followed by [14C]-oleic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Kowa

Curated by ChEMBL
LigandPNGBDBM50069900(2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of ACAT1 in 1 mg/ml rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Mus musculus)
Kowa

Curated by ChEMBL
LigandPNGBDBM50069900(2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)...)
Affinity DataIC50:  590nMAssay Description:Inhibition of ACAT1 in mouse J774 cells assessed as reduction in esterified cholesterol accumulation after 18 hrs in presence of 25-hydroxycholestero...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Mus musculus)
Kowa

Curated by ChEMBL
LigandPNGBDBM50069900(2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)...)
Affinity DataIC50:  60nMAssay Description:Inhibition of ACAT1 in mouse IC21 cells in absence of BSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed