BDBM50072664 CHEMBL3410036
SMILES Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccccc4)cc3)c12
InChI Key InChIKey=WQAGVQVBDHOHRD-UHFFFAOYSA-N
Data 13 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50072664
Affinity DataIC50: 470nMAssay Description:Inhibition of Limk1 in rat A7r5 cells assessed as reduction in cofilin phosphorylation by Western blot methodMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute
Curated by ChEMBL
Translational Research Institute
Curated by ChEMBL
Affinity DataIC50: 6.57E+3nMAssay Description:Inhibition of human ROCK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK peptide substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Translational Research Institute
Curated by ChEMBL
Translational Research Institute
Curated by ChEMBL
Affinity DataIC50: 5.54E+3nMAssay Description:Inhibition of human ROCK1 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK peptide substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair