BDBM50072697 5-Butyl-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL326092

SMILES CCCCC1Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12

InChI Key InChIKey=HKKAPCOJXICOAX-UHFFFAOYSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50072697   

TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072697(5-Butyl-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity was determined against hPR-A (human progesterone receptor) using progesterone radioligand in competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072697(5-Butyl-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-...)
Affinity DataKi:  533nMAssay Description:Displacement of Dexamethasone from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072697(5-Butyl-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-...)
Affinity DataKi:  1.33E+3nMAssay Description:Displacement of DHT from human androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072697(5-Butyl-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072697(5-Butyl-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-...)
Affinity DataEC50:  15nMAssay Description:Agonist activity was determined against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed