BDBM50072713 2,2,4-Trimethyl-5-(3-methyl-butyl)-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL114607

SMILES CC(C)CCC1Oc2ccccc2-c2ccc3NC(C)(C)C=C(C)c3c12

InChI Key InChIKey=NVTFLQJKFXTAOZ-UHFFFAOYSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50072713   

TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072713(2,2,4-Trimethyl-5-(3-methyl-butyl)-2,5-dihydro-1H-...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity was determined against hPR-A (human progesterone receptor) using progesterone radioligand in competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072713(2,2,4-Trimethyl-5-(3-methyl-butyl)-2,5-dihydro-1H-...)
Affinity DataKi:  158nMAssay Description:Displacement of Dexamethasone from human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072713(2,2,4-Trimethyl-5-(3-methyl-butyl)-2,5-dihydro-1H-...)
Affinity DataKi:  1.49E+3nMAssay Description:Displacement of DHT from human androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072713(2,2,4-Trimethyl-5-(3-methyl-butyl)-2,5-dihydro-1H-...)
Affinity DataEC50:  307nMAssay Description:Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072713(2,2,4-Trimethyl-5-(3-methyl-butyl)-2,5-dihydro-1H-...)
Affinity DataEC50:  13nMAssay Description:Agonist activity was determined against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed