BDBM50072721 2,2,4,9-Tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::2,2,4,9-tetramethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline::CHEMBL294116

SMILES CC1=CC(C)(C)Nc2ccc-3c(COc4ccc(C)cc-34)c12

InChI Key InChIKey=HMUFHZZKXUITHF-UHFFFAOYSA-N

Data  3 KI  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50072721   

TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072721(2,2,4,9-Tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chr...)
Affinity DataKi:  45nMAssay Description:Binding affinity at human progesterone receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072721(2,2,4,9-Tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chr...)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072721(2,2,4,9-Tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chr...)
Affinity DataKi:  50nMAssay Description:Binding affinity was determined against hPR-A (human progesterone receptor) using progesterone radioligand in competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072721(2,2,4,9-Tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chr...)
Affinity DataIC50:  100nMAssay Description:Effective concentration for human progesterone in T47D human breast cancer cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072721(2,2,4,9-Tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chr...)
Affinity DataEC50:  76nMAssay Description:Effective concentration for human progesterone receptor in T47D human breast cancer cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072721(2,2,4,9-Tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chr...)
Affinity DataEC50: >1.00E+3nMAssay Description:Effective concentration for human progesterone receptor in T47D human breast cancer cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072721(2,2,4,9-Tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chr...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity was determined against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072721(2,2,4,9-Tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chr...)
Affinity DataEC50:  75nMAssay Description:Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed