BDBM50075510 5-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(Z)-ylidene]-2-methoxyamino-thiazol-4-one::CHEMBL15791

SMILES CONC1=NC(=O)C(S1)=Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

InChI Key InChIKey=ZJFXWSPUWDWLPL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50075510   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075510(5-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(Z)...)
Affinity DataIC50: >2.00E+4nMAssay Description:IC50 value was determined against Prostaglandin G/H synthase 1 of human platelet rich plasma; Not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50075510(5-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(Z)...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of recombinant human COX-2 using [14C]arachidonic acid as substrate incubated for 1 mins by radiometric HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075510(5-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(Z)...)
Affinity DataIC50:  170nMAssay Description:IC50 value was determined against Prostaglandin G/H synthase 2 of J7744A.1 cell lines.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50075510(5-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(Z)...)
Affinity DataIC50:  1.70E+3nMAssay Description:IC50 against recombinant human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed