BDBM50075519 4,6-Di-tert-butyl-2-(5-methylsulfanyl-[1,3,4]thiadiazol-2-yl)-pyrimidin-5-ol::CHEMBL275188

SMILES CSc1nnc(s1)-c1nc(c(O)c(n1)C(C)(C)C)C(C)(C)C

InChI Key InChIKey=UHAUUAGUJDZJLR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50075519   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075519(4,6-Di-tert-butyl-2-(5-methylsulfanyl-[1,3,4]thiad...)
Affinity DataIC50:  97nMAssay Description:IC50 value against ovine Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075519(4,6-Di-tert-butyl-2-(5-methylsulfanyl-[1,3,4]thiad...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of recombinant human prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075519(4,6-Di-tert-butyl-2-(5-methylsulfanyl-[1,3,4]thiad...)
Affinity DataIC50:  26nMAssay Description:IC50 value against Prostaglandin G/H synthase 2 of murine J774A.1 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075519(4,6-Di-tert-butyl-2-(5-methylsulfanyl-[1,3,4]thiad...)
Affinity DataIC50:  200nMAssay Description:IC50 value against Prostaglandin G/H synthase 1 of human platelet rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed