BDBM50075539 3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-[1,2,4]thiadiazol-5-yl-cyanamide::CHEMBL1626563::CHEMBL17229

SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)-c1nsc(NC#N)n1

InChI Key InChIKey=RMARUWMZUTXBJC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50075539   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075539(3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-[1,2,4]thia...)
Affinity DataIC50:  3.20E+4nMAssay Description:IC50 value against ovine Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075539(3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-[1,2,4]thia...)
Affinity DataIC50:  1.20E+3nMAssay Description:IC50 value against Prostaglandin G/H synthase 1 of human platelet rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075539(3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-[1,2,4]thia...)
Affinity DataIC50:  11nMAssay Description:Evaluated in vitro for its inhibitory activity against Prostaglandin G/H synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075539(3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-[1,2,4]thia...)
Affinity DataIC50:  47nMAssay Description:Inhibition of recombinant human prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075539(3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-[1,2,4]thia...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibitory activity against 5-LipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075539(3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-[1,2,4]thia...)
Affinity DataIC50:  26nMAssay Description:IC50 value against Prostaglandin G/H synthase 2 of murine J774A.1 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed