BDBM50075764 4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyridine::CHEMBL160490

SMILES Clc1ccc(cc1)-c1cc(c([nH]1)-c1ccncc1)-c1ccc(Cl)cc1

InChI Key InChIKey=XUJSRSRKGLTVPA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50075764   

TargetGlucagon receptor(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075764(4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50:  220nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075764(4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50:  810nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the human glucagon receptor (GGR) expressed on CH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075764(4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50:  160nMAssay Description:Antagonist activity at human glucagon receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075764(4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50:  190nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075764(4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50:  4.20E+4nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the human glucagon receptor (GGR) expressed on CH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075764(4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50:  160nMAssay Description:Inhibitory activity against p38-alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed