BDBM50077581 (R)-2-(Benzylamino-methyl)-3,4,7,9-tetrahydro-2H-pyrano[2,3-e]indol-8-one::CHEMBL303556

SMILES O=C1Cc2c(N1)ccc1CC[C@H](CNCc3ccccc3)Oc21

InChI Key InChIKey=NPATVCXCHCPFCB-OAHLLOKOSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50077581   

TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077581((R)-2-(Benzylamino-methyl)-3,4,7,9-tetrahydro-2H-p...)
Affinity DataKi:  0.140nMAssay Description:Affinity of compound for D2 receptor in rat striatal membrane determined for agonist state (high affinity state, D2 High) [3H]quinpirole as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077581((R)-2-(Benzylamino-methyl)-3,4,7,9-tetrahydro-2H-p...)
Affinity DataKi:  0.140nMAssay Description:In vitro high binding affinity towards Dopamine receptor D2 by the displacement of [3H]-quinpirole radioligand in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077581((R)-2-(Benzylamino-methyl)-3,4,7,9-tetrahydro-2H-p...)
Affinity DataKi:  2.40nMAssay Description:Affinity for the Human Dopamine receptor D3 was determined using membranes from CHO cells labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077581((R)-2-(Benzylamino-methyl)-3,4,7,9-tetrahydro-2H-p...)
Affinity DataKi:  5.90nMAssay Description:In vitro low binding affinity towards Dopamine receptor D2 by the displacement of [3H]-spiperone radioligand in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077581((R)-2-(Benzylamino-methyl)-3,4,7,9-tetrahydro-2H-p...)
Affinity DataKi:  5.90nMAssay Description:Affinity of compound for Dopamine receptor D2 in rat striatal membrane determined for antagonist state (low affinity state, D2 Low) with [3H]spiperon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077581((R)-2-(Benzylamino-methyl)-3,4,7,9-tetrahydro-2H-p...)
Affinity DataKi:  8.5nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [3H]-8-OH-DPAT radioligand in rat hippocampal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077581((R)-2-(Benzylamino-methyl)-3,4,7,9-tetrahydro-2H-p...)
Affinity DataKi:  9.30nMAssay Description:Affinity for the Dopamine receptor D2S was determined using membranes from CHO cells labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077581((R)-2-(Benzylamino-methyl)-3,4,7,9-tetrahydro-2H-p...)
Affinity DataKi:  359nMAssay Description:Affinity for the Human Dopamine receptor D4 was determined using membranes from CHO cells labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed