BDBM50077592 7-Chloro-4-[2-(1,3-dihydro-isoindol-2-yl)-ethoxy]-1,3-dihydro-indol-2-one::CHEMBL64524

SMILES Clc1ccc(OCCN2Cc3ccccc3C2)c2CC(=O)Nc12

InChI Key InChIKey=NTOGEDXEDRMFKP-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50077592   

TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077592(7-Chloro-4-[2-(1,3-dihydro-isoindol-2-yl)-ethoxy]-...)
Affinity DataKi:  0.440nMAssay Description:In vitro high binding affinity towards Dopamine receptor D2 by the displacement of [3H]-quinpirole radioligand in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077592(7-Chloro-4-[2-(1,3-dihydro-isoindol-2-yl)-ethoxy]-...)
Affinity DataKi:  2.90nMAssay Description:In vitro low binding affinity towards Dopamine receptor D2 by the displacement of [3H]-spiperone radioligand in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077592(7-Chloro-4-[2-(1,3-dihydro-isoindol-2-yl)-ethoxy]-...)
Affinity DataKi:  41nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [3H]-8-OH-DPAT radioligand in rat hippocampal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed