BDBM50079183 (2S)-amino(3,5-dihydroxyphenyl)ethanoic acid::(S)-3,5-DHPG::(S)-Amino-(3,5-dihydroxy-phenyl)-acetic acid::3,5-DHPG::Amino-(3,5-dihydroxy-phenyl)-acetic acid::Amino-(3,5-dihydroxy-phenyl)-acetic acid(S-DHPG)::CHEMBL39221::amino(3,5-dihydroxyphenyl)acetic acid

SMILES N[C@H](C(O)=O)c1cc(O)cc(O)c1

InChI Key InChIKey=HOOWCUZPEFNHDT-ZETCQYMHSA-N

Data  11 KI  4 EC50

PDB links: 40 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50079183   

TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataKi:  900nMAssay Description:Binding affinity at Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataKi:  1.90E+3nMAssay Description:Agonist potency against cloned metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataKi:  2.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataKi:  6.60E+3nMAssay Description:Agonist potency against cloned human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataKi:  6.60E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataKi: >1.00E+6nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataKi: >1.00E+6nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataKi: >1.00E+6nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 7 (mGluR-7).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity at Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataKi: >1.00E+6nMAssay Description:Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataEC50: >1.00E+5nMAssay Description:Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inacti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataEC50:  6.60E+3nMAssay Description:Compound was tested for its agonist activity against Ser165 and Thr188 (Metabotropic glutamate receptor 1) receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataEC50:  6.50E+4nMAssay Description:Agonistic activity against phospholipase C (PLC) was determined in adult rat hippocampal slicesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataEC50:  1.09E+4nMAssay Description:Compound was tested for ability to stimulate metabotropic glutamate receptor (mGluR) mediated phosphoinositide hydrolysis in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails