BDBM50080337 (R)-1-{2-[2,2-Bis-(3-methyl-thiophen-2-yl)-vinyloxy]-ethyl}-piperidine-3-carboxylic acid; hydrochloride::CHEMBL554210

SMILES [#6]-c1ccsc1\[#6](=[#6]/[#8]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6@H](-[#6]-1)-[#6](-[#8])=O)-c1sccc1-[#6]

InChI Key InChIKey=LDRYKGXVXNQQTQ-MRXNPFEDSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50080337   

TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50080337((R)-1-{2-[2,2-Bis-(3-methyl-thiophen-2-yl)-vinylox...)
Affinity DataKi:  14nMAssay Description:In vitro inhibition of [3H]GABA uptake at the Sodium- and chloride-dependent GABA transporter 1 (GAT-1) uptake site in rat brain synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50080337((R)-1-{2-[2,2-Bis-(3-methyl-thiophen-2-yl)-vinylox...)
Affinity DataIC50:  14nMAssay Description:Inhibition of mouse GAT1 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50080337((R)-1-{2-[2,2-Bis-(3-methyl-thiophen-2-yl)-vinylox...)
Affinity DataIC50:  10nMAssay Description:Inhibition of rat brain synaptosomes GAT1 assessed as inhibition of [3H]GABA uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed