BDBM50080464 ALR2 inhibitor, 12::CHEMBL1405739

SMILES OC(=O)Cn1c2ccccc2c2nnc(S)nc12

InChI Key InChIKey=LCMDWJXBUZDEKA-UHFFFAOYSA-N

Data  1 KI  11 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50080464   

TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataKi:  89nMAssay Description:Uncompetitive inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate by double reciprocal plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataIC50:  2.14E+4nMAssay Description:Inhibition of human AKR1B10 using D-glucuronate as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataIC50:  98nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B7(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataIC50:  4.06E+4nMAssay Description:Inhibition of Wistar rat kidney aldehyde reductase using D-glucuronate as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataIC50:  97nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataIC50:  116nMAssay Description:Inhibition of rat lens ALR2 using D,L-glyceraldehyde as substrate incubated for 1 min and measured up to 4 mins using H2O-dissolved compound by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataIC50:  102nMAssay Description:Inhibition of human AKR1B1 expressed in Escherichia coli using D,L-glyceraldehyde as substrate incubated for 1 min and measured up to 4 mins using by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataIC50:  146nMAssay Description:Inhibition of rat lens ALR2 using methylglyoxal as substrate incubated for 1 min and measured up to 4 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataIC50:  1.16E+3nMAssay Description:Inhibition of rat lens ALR2 using 4-hydroxynonenal glutathione as substrate incubated for 1 min and measured up to 4 mins by spectrophotometric analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataIC50:  644nMAssay Description:Inhibition of rat lens ALR2 using 4-hydroxynonenal as substrate incubated for 1 min and measured up to 4 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataIC50:  176nMAssay Description:Inhibition of rat lens ALR2 using D,L-glyceraldehyde as substrate incubated for 1 min and measured up to 4 mins using 1% DMSO-dissolved compound by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataKd:  38nMpH: 8.5Assay Description:The anti-His antibody (His Capture Kit, GE Healthcare) was immobilized on sensor chip CM5 (GE Healthcare), in a Biacore T200 or Biacore S200 instrume...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataIC50:  57nMAssay Description:Inhibition of human recombinant AKR1B1 using D-glucuronate as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed