BDBM50081918 5-(4-Propoxy-benzyl)-pyrimidine-2,4-diamine::CHEMBL326989
SMILES CCCOc1ccc(Cc2cnc(N)nc2N)cc1
InChI Key InChIKey=BRKLJPVCTPAPFG-UHFFFAOYSA-N
Data 8 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50081918
Affinity DataKi: 6.40nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataKi: 15.1nMAssay Description:Inhibitory activity against wild-type dihydrofolate reductase (S108N DHFR)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataKi: 212nMAssay Description:Inhibitory activity against double mutant dihydrofolate reductase (C59R+S108N DHFR)More data for this Ligand-Target Pair
Affinity DataKi: 230nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Trypanosoma cruzi.More data for this Ligand-Target Pair
Affinity DataKi: 330nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Leishmania major.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataKi: 1.09E+3nMAssay Description:Inhibitory activity against triple mutant dihydrofolate reductase (C59R S108 NI164L DHFR)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataKi: 1.52E+3nMAssay Description:Inhibitory activity against quadruple mutant dihydrofolate reductase (N51I C59R S108N I164L DHFR)More data for this Ligand-Target Pair
Affinity DataKi: 2.90E+3nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair