BDBM50081918 5-(4-Propoxy-benzyl)-pyrimidine-2,4-diamine::CHEMBL326989

SMILES CCCOc1ccc(Cc2cnc(N)nc2N)cc1

InChI Key InChIKey=BRKLJPVCTPAPFG-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50081918   

TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081918(5-(4-Propoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  6.40nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand

Curated by ChEMBL
LigandPNGBDBM50081918(5-(4-Propoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  15.1nMAssay Description:Inhibitory activity against wild-type dihydrofolate reductase (S108N DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand

Curated by ChEMBL
LigandPNGBDBM50081918(5-(4-Propoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  212nMAssay Description:Inhibitory activity against double mutant dihydrofolate reductase (C59R+S108N DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081918(5-(4-Propoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  230nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Trypanosoma cruzi.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081918(5-(4-Propoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  330nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Leishmania major.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand

Curated by ChEMBL
LigandPNGBDBM50081918(5-(4-Propoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  1.09E+3nMAssay Description:Inhibitory activity against triple mutant dihydrofolate reductase (C59R S108 NI164L DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand

Curated by ChEMBL
LigandPNGBDBM50081918(5-(4-Propoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  1.52E+3nMAssay Description:Inhibitory activity against quadruple mutant dihydrofolate reductase (N51I C59R S108N I164L DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081918(5-(4-Propoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed