BDBM50082056 5-Ethyl-5-thiophen-2-yl-6-oxa-10,10b-diaza-benzo[e]azulen-4-one::CHEMBL138969

SMILES CCC1(Oc2cccnc2-n2cccc2C1=O)c1cccs1

InChI Key InChIKey=TXUABTMIUKWMLO-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50082056   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082056(5-Ethyl-5-thiophen-2-yl-6-oxa-10,10b-diaza-benzo[e...)
Affinity DataKi:  45nMAssay Description:In vitro inhibitory activity of the compound against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution K103NMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082056(5-Ethyl-5-thiophen-2-yl-6-oxa-10,10b-diaza-benzo[e...)
Affinity DataKi:  90nMAssay Description:In vitro inhibitory activity of the compound against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution V106AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082056(5-Ethyl-5-thiophen-2-yl-6-oxa-10,10b-diaza-benzo[e...)
Affinity DataKi:  90nMAssay Description:In vitro inhibitory activity of the compound against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution L100IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082056(5-Ethyl-5-thiophen-2-yl-6-oxa-10,10b-diaza-benzo[e...)
Affinity DataKi:  93nMAssay Description:In vitro inhibitory activity against HIV-1 wild type reverse transcriptase (RT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082056(5-Ethyl-5-thiophen-2-yl-6-oxa-10,10b-diaza-benzo[e...)
Affinity DataKi:  430nMAssay Description:In vitro inhibitory activity of the compound against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution Y181IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082056(5-Ethyl-5-thiophen-2-yl-6-oxa-10,10b-diaza-benzo[e...)
Affinity DataKi:  475nMAssay Description:In vitro inhibitory activity of the compound against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution Y188LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed