BDBM50082060 5-Ethyl-5-phenyl-6-oxa-10,10b-diaza-benzo[e]azulen-4-one::CHEMBL137838

SMILES CCC1(Oc2cccnc2-n2cccc2C1=O)c1ccccc1

InChI Key InChIKey=GASTXZXBZWXIJZ-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50082060   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082060(5-Ethyl-5-phenyl-6-oxa-10,10b-diaza-benzo[e]azulen...)
Affinity DataKi:  22nMAssay Description:In vitro inhibitory activity against HIV-1 wild type reverse transcriptase (RT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082060(5-Ethyl-5-phenyl-6-oxa-10,10b-diaza-benzo[e]azulen...)
Affinity DataKi:  40nMAssay Description:In vitro inhibitory activity of the compound against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution L100IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082060(5-Ethyl-5-phenyl-6-oxa-10,10b-diaza-benzo[e]azulen...)
Affinity DataKi:  70nMAssay Description:In vitro inhibitory activity of the compound against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution V106AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082060(5-Ethyl-5-phenyl-6-oxa-10,10b-diaza-benzo[e]azulen...)
Affinity DataKi:  300nMAssay Description:In vitro inhibitory activity of the compound against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution K103NMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082060(5-Ethyl-5-phenyl-6-oxa-10,10b-diaza-benzo[e]azulen...)
Affinity DataKi:  1.50E+3nMAssay Description:In vitro inhibitory activity of the compound against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution Y188LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Universita' Degli Studi Di Salerno

Curated by ChEMBL
LigandPNGBDBM50082060(5-Ethyl-5-phenyl-6-oxa-10,10b-diaza-benzo[e]azulen...)
Affinity DataKi:  4.00E+3nMAssay Description:In vitro inhibitory activity of the compound against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution Y181IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed