BDBM50083899 5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one::CHEMBL13458::Ro-05-2921

SMILES O=C1CN=C(c2ccccc2)c2ccccc2N1

InChI Key InChIKey=IVUAAOBNUNMJQC-UHFFFAOYSA-N

Data  9 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50083899   

TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083899(5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |...)
Affinity DataKi:  140nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha5beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083899(5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |...)
Affinity DataKi:  140nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083899(5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |...)
Affinity DataKi:  233nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha2beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083899(5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |...)
Affinity DataKi:  233nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083899(5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |...)
Affinity DataKi:  286nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083899(5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |...)
Affinity DataKi:  288nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha1beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083899(5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |...)
Affinity DataKi:  350nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083899(5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |...)
Affinity DataKi:  350nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha3beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083899(5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |...)
Affinity DataKi: >3.00E+3nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50083899(5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human KDAC3 using FITC-labeled p53 acetylated peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50083899(5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human KDAC6 using FITC-labeled histone H4 acetylated peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Schistosoma mansoni)
Washington University

Curated by ChEMBL
LigandPNGBDBM50083899(5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Schistosoma mansoni KDAC8 using (FAM)-labeled peptide as substrate after 60 mins by microfluidic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Harvard University

Curated by ChEMBL
LigandPNGBDBM50083899(5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |...)
Affinity DataIC50:  2.85E+6nMAssay Description:Binding affinity of compound towards Benzodiazepine receptor in a competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50083899(5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human KDAC8 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50083899(5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human KDAC1 using substrate A after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed