BDBM50083940 4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid (0.2H2O)::CHEMBL184215::CHEMBL278763::Sacchettini_6

SMILES OC(=O)C(=O)CC(=O)c1cccc(Cl)c1

InChI Key InChIKey=OGKORXSMGAWLDU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50083940   

TargetMalate synthase G [C619A](Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
D3R/Abbott

LigandPNGBDBM50083940(4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...)
Affinity DataIC50:  170nMAssay Description:DNTB-Coupled_Enzyme_AssayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA excision repair protein ERCC-5(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50083940(4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...)
Affinity DataIC50:  1.31E+4nMAssay Description:Concentration required for 50% inhibition of Xeroderma pigmentosum GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50083940(4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...)
Affinity DataIC50:  6.96E+3nMAssay Description:Concentration required for 50% inhibition of Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083940(4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...)
Affinity DataIC50:  320nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed