BDBM50084726 4-(Biphenyl-4-carbonyl)-1-(4-methoxy-benzenesulfonyl)-piperazine-2-carboxylic acid hydroxyamide::CHEMBL125598

SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)C(=O)c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=KXZZWRQJKQVMKR-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50084726   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084726(4-(Biphenyl-4-carbonyl)-1-(4-methoxy-benzenesulfon...)
Affinity DataIC50:  0.900nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084726(4-(Biphenyl-4-carbonyl)-1-(4-methoxy-benzenesulfon...)
Affinity DataIC50:  43nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084726(4-(Biphenyl-4-carbonyl)-1-(4-methoxy-benzenesulfon...)
Affinity DataIC50:  0.900nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFalcilysin(Plasmodium falciparum (isolate 3D7))
California State University

Curated by ChEMBL
LigandPNGBDBM50084726(4-(Biphenyl-4-carbonyl)-1-(4-methoxy-benzenesulfon...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Plasmodium falciparum 3D7 FLN (55 to 1193 residues) expressed in Escherichia coli BL21 using Dabcyl-HKRHSFRMRG-EDANS as substrate prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084726(4-(Biphenyl-4-carbonyl)-1-(4-methoxy-benzenesulfon...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084726(4-(Biphenyl-4-carbonyl)-1-(4-methoxy-benzenesulfon...)
Affinity DataIC50:  0.891nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084726(4-(Biphenyl-4-carbonyl)-1-(4-methoxy-benzenesulfon...)
Affinity DataIC50:  23nMAssay Description:Binding affinity towards matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084726(4-(Biphenyl-4-carbonyl)-1-(4-methoxy-benzenesulfon...)
Affinity DataIC50:  931nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-7 (MMP-7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed