BDBM50085415 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one::3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one::3-[1-(3,5-Dibromo-4-hydroxy-phenyl)-meth-(Z)-ylidene]-5-iodo-1,3-dihydro-indol-2-one::CHEMBL72365::G6416 (GW5074)::GW-5074

SMILES Oc1c(Br)cc(\C=C2/C(=O)Nc3ccc(I)cc23)cc1Br

InChI Key InChIKey=LMXYVLFTZRPNRV-KMKOMSMNSA-N

Data  24 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50085415   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of PLK1 (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  9nMAssay Description:Inhibition of cRAF1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein kinase C alpha type/glutamine gamma-glutamyltransferase 2(Homo sapiens (Human))
Duke University Medical Center

LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  1.50E+4nMT: 2°CAssay Description:In order to eliminated fluorescence interference, chemicals were subjected to a secondary screening using colorimetric BP incorporation assay. TGase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of cRAF1 (unknown origin) at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of BRAF V599E mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  11nMAssay Description:Inhibition of BRAF (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyocilin(Homo sapiens)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataKd:  3.35E+4nMAssay Description:Binding affinity myocilin-OLF domain (unknown origin) by SRP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF15(Homo sapiens)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of recombinant His6-tagged Kif15 ATPase activity (N420 residues) (unknown origin) expressed in HeLa cells using microtubule as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  29.3nMAssay Description:Inhibition of human BRAF using MEK1 (K97R) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  279nMAssay Description:Inhibition of human CK2A using RRRDDDSDDD as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 4(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  4.38E+3nMAssay Description:Inhibition of human DYRK4 using RRRFRPASPLRGPPK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of human RIPK3 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase A-Raf(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  14.6nMAssay Description:Inhibition of human ARAF using MEK1 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  10.6nMAssay Description:Inhibition of human RAF1 using MEK1 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 20(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  1.89E+3nMAssay Description:Inhibition of human ZAK using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  13nMAssay Description:Inhibition of BRAF (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of human CRAF using MEK1 (K97R) as substrate in presence of [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human BRAF using MEK1 (K97R) as substrate in presence of [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of human BRAF V600E mutant using MEK1 (K97R) as substrate in presence of [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of BRAF (unknown origin) in presence of ATP by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Raf-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) using MEK1 (K97R) as substrate in presence of [gamma-33P]ATP by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHuntingtin(Homo sapiens (Human))TBA
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataKd:  100nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataKd:  100nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  230nMAssay Description:Inhibition of N-terminal GST-tagged human PLK4 (1 to 391 amino acids) expressed in Escherichia coli using TMB as substrate after 30 mins by indirect ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed