BDBM50087004 8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-methyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL27729

SMILES CN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3c(Cl)ccc(Cl)c3C2)C1=O

InChI Key InChIKey=KQCKYRUSOWOAAT-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50087004   

TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087004(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataKi:  2.60nMAssay Description:Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087004(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataKi:  3.30nMAssay Description:Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087004(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataKi:  17nMAssay Description:Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087004(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataKi:  313nMAssay Description:Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed