BDBM500892 (S)-7-((6- ((dimethylamino)- methyl)-5- (1-methyl-2- oxopiperidin- 4-yl)pyridin-2- yl)amino)-4- (7-fluoroimidazo [1,2-a]pyridin- 3-yl)isoindolin- 1-one::US11021481, Compound I-556::US11078201, Compound I-556::US11548890, Compound I-556

SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1[C@H]1CCN(C)C(=O)C1

InChI Key InChIKey=GSBJHJROHHXKQM-KRWDZBQOSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500892   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500892((S)-7-((6- ((dimethylamino)- methyl)-5- (1-methyl-...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500892((S)-7-((6- ((dimethylamino)- methyl)-5- (1-methyl-...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500892((S)-7-((6- ((dimethylamino)- methyl)-5- (1-methyl-...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500892((S)-7-((6- ((dimethylamino)- methyl)-5- (1-methyl-...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500892((S)-7-((6- ((dimethylamino)- methyl)-5- (1-methyl-...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent