BDBM50089245 CHEMBL3577885

SMILES C[C@@H](N(Cc1cccc(c1)C(O)=O)C(=O)c1cnc2ccccc2c1)c1ccc(F)cc1

InChI Key InChIKey=BXNMZRPTQFVRFA-QGZVFWFLSA-N

Data  1 KI  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50089245   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

LigandBDBM50089245(CHEMBL3577885)Copy SMILESCopy InChI

Affinity DataKi: >1.59E+4nMAssay Description:Inhibition of dofetilide binding to human ERGMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

LigandBDBM50089245(CHEMBL3577885)Copy SMILESCopy InChI

Affinity DataIC50:  181nMAssay Description:Antagonist activity against human recombinant TRPM8 expressed in CHO T-rex cells assessed as inhibition of WS12-induced calcium response pre-incubate...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

LigandBDBM50089245(CHEMBL3577885)Copy SMILESCopy InChI

Affinity DataIC50:  103nMAssay Description:Antagonist activity against human TRPM8 by single cell patch clamp electrophysiologyMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI