BDBM50092071 CHEMBL3582420::US9296728, 18

SMILES COc1cc(ccc1\C=C(/C#N)C(O)=O)N(CC(C)C)CC(C)C

InChI Key InChIKey=JJFBEGVKIVBBHB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50092071   

TargetMonocarboxylate transporter 1(Rattus norvegicus (Rat))
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50092071(CHEMBL3582420 | US9296728, 18)
Affinity DataIC50:  15nMpH: 7.43 T: 2°CAssay Description:The entire lactate uptake studies for the inhibition of MCT1 were carried out on RBE4 (Rat Brain Endothelial 4) cells. The expression of MCT1 on thes...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMonocarboxylate transporter 4(Homo sapiens (Human))TBA
LigandPNGBDBM50092071(CHEMBL3582420 | US9296728, 18)
Affinity DataIC50:  17nMAssay Description:Inhibition of MCT4 (unknown origin) assessed as reduction in [14C]lactate uptake incubated for 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))TBA
LigandPNGBDBM50092071(CHEMBL3582420 | US9296728, 18)
Affinity DataIC50:  11nMAssay Description:Inhibition of MCT1 (unknown origin) assessed as reduction in [14C]lactate uptake incubated for 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMonocarboxylate transporter 1(Rattus norvegicus (Rat))
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50092071(CHEMBL3582420 | US9296728, 18)
Affinity DataIC50:  11nMAssay Description:Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed