BDBM50095310 CHEMBL3589894

SMILES CNC(=O)c1ccc(c(N)n1)-c1cc(Cl)cc(Cl)c1Cl

InChI Key InChIKey=HPIUHDCRVYDAEJ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50095310   

TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095310(CHEMBL3589894)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human Nav1.2 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095310(CHEMBL3589894)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human Nav1.3 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095310(CHEMBL3589894)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human Nav1.7 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095310(CHEMBL3589894)
Affinity DataIC50:  190nMAssay Description:Inhibition of human Nav1.8/beta1 expressed in HEK293 cells by manual patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095310(CHEMBL3589894)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095310(CHEMBL3589894)
Affinity DataIC50:  1.28E+4nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by IonWorks Quattro selectivity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095310(CHEMBL3589894)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by IonWorks Quattro selectivity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095310(CHEMBL3589894)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095310(CHEMBL3589894)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095310(CHEMBL3589894)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by IonWorks Quattro selectivity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed