BDBM50095423 5-tert-Butyl-3-(3-phenyl-ureido)-thiophene-2-carboxylic acid methyl ester::CHEMBL19148::methyl 5-tert-butyl-3-(3-phenylureido)thiophene-2-carboxylate

SMILES COC(=O)c1sc(cc1NC(=O)Nc1ccccc1)C(C)(C)C

InChI Key InChIKey=LMTOUHLEUVLGSR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50095423   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50095423(5-tert-Butyl-3-(3-phenyl-ureido)-thiophene-2-carbo...)
Affinity DataIC50:  290nMAssay Description:In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50095423(5-tert-Butyl-3-(3-phenyl-ureido)-thiophene-2-carbo...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of B-Raf1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50095423(5-tert-Butyl-3-(3-phenyl-ureido)-thiophene-2-carbo...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of RAF1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50095423(5-tert-Butyl-3-(3-phenyl-ureido)-thiophene-2-carbo...)
Affinity DataIC50:  290nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50095423(5-tert-Butyl-3-(3-phenyl-ureido)-thiophene-2-carbo...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibitory concentration against raf kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50095423(5-tert-Butyl-3-(3-phenyl-ureido)-thiophene-2-carbo...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of CRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed