BDBM50096906 CHEMBL154745::US10227373, Compound D-3-Deazaisoneplanocin

SMILES Nc1nccc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O

InChI Key InChIKey=OMKHWTRUYNAGFG-IEBDPFPHSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50096906   

TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50096906(CHEMBL154745 | US10227373, Compound D-3-Deazaisone...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of SAH hydrolase (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50096906(CHEMBL154745 | US10227373, Compound D-3-Deazaisone...)
Affinity DataIC50:  80nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50096906(CHEMBL154745 | US10227373, Compound D-3-Deazaisone...)
Affinity DataIC50:  440nMAssay Description:Inhibition of recombinant human placental AdoHcy hydrolase expressed in Escherichia coli BL21 using AdoHcy as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Oryctolagus cuniculus (Rabbit))
Auburn University

US Patent
LigandPNGBDBM50096906(CHEMBL154745 | US10227373, Compound D-3-Deazaisone...)
Affinity DataIC50:  3.19nMAssay Description:As a consequence of "D"-Isoneplanocin and "L"-Isoneplanocin, being isomers of Neplanocin A, which on one hand is a potent inhibitor of S-adenosylhomo...More data for this Ligand-Target Pair
In DepthDetails US Patent